Speculation: A link between Chronic Fatigue and Post-Vaccine syndrome?
Erratum - put “Long Covid” in title originally - meant “Post-Vaccine Syndrome.” Although these two may be one and the same in many cases.
Problems with the regulation of mRNA transcription process might be what triggers chronic fatigue; and this may provide a clue and what is causing post-vaccine syndrome, a syndrome suffered by people who have taken the mRNA vaccines.
MicroRNA or miRNA is not the same as mRNA (messenger RNA)
mRNA is involved in protein synthesis. mRNA is transcribed from the DNA in the cell, and is then transported to where the protein making process makes a protein from the mRNA.
MicroRNAs are non-coding RNAs. One of the roles of MicroRNA, or miRNA, is to regulate mRNA transcription, according to an article in Frontiers1:
MicroRNAs (miRNAs) are a class of non-coding RNAs that play important roles in regulating gene expression. The majority of miRNAs are transcribed from DNA sequences into primary miRNAs and processed into precursor miRNAs, and finally mature miRNAs. In most cases, miRNAs interact with the 3′ untranslated region (3′ UTR) of target mRNAs to induce mRNA degradation and translational repression. However, interaction of miRNAs with other regions, including the 5′ UTR, coding sequence, and gene promoters, have also been reported. Under certain conditions, miRNAs can also activate translation or regulate transcription.
A literature review from 2019, Eloy et al, looking at the ‘epigenetic elements’ of Chronic Fatigue cited studies that found that changes in miRNA, influenced by environment, illnesses, or toxins, may be causing Chronic Fatigue syndrome by suppressing the mechanism that regulates mRNA transcription2.
One of the studies they looked at found that expression level of particular miRNAs is decreased in Chronic Fatigue sufferers.
There was a significant reduction in the expression levels of miR-21, in both the NK and CD8+T cells in the CFS/ME sufferers. Additionally, the expression of miR-17-5p, miR-10a, miR-103, miR-152, miR-146a, miR-106, miR-223 and miR-191 was significantly decreased in NK cells of CFS/ME patients in comparison to the non-fatigued controls3.
If those miRNAs are missing, I wonder if it means that Chronic Fatigue sufferers cells are less able to regulate the uncontrolled expression of the Spike Protein engendered by the vaccines?
The symptoms of Chronic Fatigue are:
postexertional malaise, or aggravation of symptoms after physical challenge, orthostatic intolerance, cognitive deficiencies, unrefreshing sleep, and flu-like symptoms,
This is of course very similar to Long Covid, or Post Vaccine Syndrome.
If the mRNA transcription process has been mucked about with by mRNA vaccines that virtually hijack that process to make Spike protein, I suppose it would not be surprising that a type of Chronic Fatigue might be associated with the mRNA vaccines.
Here’s the abstract of Eloy et al:
Purpose
Studies to determine epigenetic changes associated with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) remain scarce; however, current evidence clearly shows that methylation patterns of genomic DNA and noncoding RNA profiles of immune cells differ between patients and healthy subjects, suggesting an active role of these epigenetic mechanisms in the disease. The present study compares and contrasts the available ME/CFS epigenetic data in an effort to evidence overlapping pathways capable of explaining at least some of the dysfunctional immune parameters linked to this disease.
Methods
A systematic search of the literature evaluating the ME/CFS epigenome landscape was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Differential DNA methylation and noncoding RNA differential expression patterns associated with ME/CFS were used to screen for the presence of transposable elements using the Dfam browser, a search program nurtured with the Repbase repetitive sequence database and the RepeatMasker annotation tool.
Findings
Unexpectedly, particular associations of transposable elements and ME/CFS epigenetic hallmarks were uncovered. A model for the disease emerged involving transcriptional induction of endogenous dormant transposons and structured cellular RNA interactions, triggering the activation of the innate immune system without a concomitant active infection.
Implications
Repetitive sequence filters (ie, RepeatMasker) should be avoided when analyzing transcriptomic data to assess the potential participation of repetitive sequences (“junk repetitive DNA”), representing >45% of the human genome, in the onset and evolution of ME/CFS. In addition, transposable element screenings aimed at designing cost-effective, focused empirical assays that can confirm or disprove the suspected involvement of transposon transcriptional activation in this disease, following the pilot strategy presented here, will require databases gathering large ME/CFS epigenetic datasets.
References
Eloy Almenar-Pérez, Tamara Ovejero, Teresa Sánchez-Fito, José A. Espejo, Lubov Nathanson, Elisa Oltra, Epigenetic Components of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Uncover Potential Transposable Element Activation, Clinical Therapeutics, Volume 41, Issue 4, 2019, Pages 675-698, ISSN 0149-2918, https://doi.org/10.1016/j.clinthera.2019.02.012 https://www.sciencedirect.com/science/article/abs/pii/S0149291819300724
O'Brien Jacob, Hayder Heyam, Zayed Yara, Peng Chun Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation Frontiers in Endocrinology, Volume 9 2018 DOI=10.3389/fendo.2018.00402 ISSN=1664-2392 https://www.frontiersin.org/articles/10.3389/fendo.2018.00402
Ekua W. Brenu, Kevin J. Ashton, Mieke van Driel, Donald R. Staines, Daniel Peterson, Gunn M. Atkinson, Sonya M. Marshall-Gradisnik, Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Journal of Affective Disorders, Volume 141, Issues 2–3, 2012, Pages 261-269, ISSN 0165-0327, https://doi.org/10.1016/j.jad.2012.03.037. https://www.sciencedirect.com/science/article/pii/S0165032712002376
O'Brien Jacob, Hayder Heyam, Zayed Yara, Peng Chun Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation Frontiers in Endocrinology, Volume 9 2018 DOI=10.3389/fendo.2018.00402 ISSN=1664-2392 https://www.frontiersin.org/articles/10.3389/fendo.2018.00402
Eloy Almenar-Pérez, Tamara Ovejero, Teresa Sánchez-Fito, José A. Espejo, Lubov Nathanson, Elisa Oltra, Epigenetic Components of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Uncover Potential Transposable Element Activation, Clinical Therapeutics, Volume 41, Issue 4, 2019, Pages 675-698, ISSN 0149-2918, https://doi.org/10.1016/j.clinthera.2019.02.012 https://www.sciencedirect.com/science/article/abs/pii/S0149291819300724
Ekua W. Brenu, Kevin J. Ashton, Mieke van Driel, Donald R. Staines, Daniel Peterson, Gunn M. Atkinson, Sonya M. Marshall-Gradisnik, Cytotoxic lymphocyte microRNAs as prospective biomarkers for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis, Journal of Affective Disorders, Volume 141, Issues 2–3, 2012, Pages 261-269, ISSN 0165-0327, https://doi.org/10.1016/j.jad.2012.03.037. https://www.sciencedirect.com/science/article/pii/S0165032712002376